翻訳と辞書
Words near each other
・ Interleukin 27
・ Interleukin 27 receptor, alpha subunit
・ Interleukin 28
・ Interleukin 28 receptor, alpha subunit
・ Interleukin 28B
・ Interleukin 29
・ Interleukin 3
・ Interleukin 30
・ Interleukin 31
・ Interleukin 32
・ Interleukin 33
・ Interleukin 34
・ Interleukin 35
・ Interleukin 36 receptor antagonist
・ Interleukin 37
Interleukin 4
・ Interleukin 5
・ Interleukin 5 receptor alpha subunit
・ Interleukin 6
・ Interleukin 7
・ Interleukin 8
・ Interleukin 8 receptor, alpha
・ Interleukin 8 receptor, beta
・ Interleukin 9
・ Interleukin receptor
・ Interleukin-1 receptor
・ Interleukin-1 receptor family
・ Interleukin-1 receptor-associated kinase
・ Interleukin-1 receptor–associated kinase 4 deficiency
・ Interleukin-10 receptor


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Interleukin 4 : ウィキペディア英語版
Interleukin 4

The interleukin 4 (IL4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells subsequently produce additional IL-4 in a positive feedback loop. The cell that initially produces IL-4, thus inducing Th0 differentiation, has not been identified, but recent studies suggest that basophils may be the effector cell. It is closely related and has functions similar to Interleukin 13.
== Function ==

It has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of B cells into plasma cells. It is a key regulator in humoral and adaptive immunity. IL-4 induces B-cell class switching to IgE, and up-regulates MHC class II production. IL-4 decreases the production of Th1 cells, macrophages, IFN-gamma, and dendritic cell IL-12.
Overproduction of IL-4 is associated with allergies.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「Interleukin 4」の詳細全文を読む



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